FORMULATION OF METFORMIN TRANSDERMAL PATCHES (TDDS) EMPLOYING TWO POLYMERS FUSION

Abstract

The purpose of this research was to determine whether or not the polymeric combinations of HPMC and ethyl cellulose could be used to create an effective matrix-type transdermal drug delivery system (TDDS) of Metformin HCL (EC). In a solvent system of dichloromethane and methanol (1:1), 6 matrix patches were produced employing these polymeric materials with propylene Glycol as a plasticizer and vegetable oils (eucalyptus oil) as permeation enhancers. Weight, medicament content, water content, hydration uptake, flatness, folding durability, and thickness were all measured and analysed to describe the formulations. Scanning electron microscopy (SEM) of the generated TDDS were recorded to see the drug - delivery pattern, and the stability of the preparations and in vitro dissolution of the trial formulations were utilized to calculate the quantity of metformin HCL in the patches. The FTIR spectroscopy technique was used to investigate drug-excipient interactions. Drug distribution homogeneity in the matrix was confirmed by in vitro dissolution tests, and maximal drug release in 24 hours was achieved with formulation F6 (containing Eucalyptus oil).